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Causes of secondary lymphedema - this type of lymphedema has several possible causes, including: Cancer surgery - cancer may spread through the body through the lymphatic system. Sometimes surgeons remove lymph nodes to stop the spread. There is a risk the lymphatic system may be affected, leading to lymphedema. Surgery for breast cancer, skin cancer, vulval cancer, cervical cancer, some other female cancers, bladder cancer and penile cancer carry a significant risk of subsequent lymphedema. Radiation therapy (radiotherapy) - the use of radiation to destroy cancerous tissue can sometimes damage nearby healthy tissue as well. When radiotherapy is used to destroy cancerous cells that are or may be present in the lymph nodes or vessels, there is a risk of node/vessel damage, with subsequent damage to the lymphatic system, resulting in lymphedema. Infections - severe cellulitis infection, a type of skin infection, may damage tissue around the lymph nodes or vessels. This may lead to scarring, increasing the risk of lymphedema. 
 
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Some parasite infections which occur in tropical parts of the world can also increase the risk of lymphedema. Inflammatory conditions - some conditions which cause tissue to swell (become inflamed) may permanently damage the lymphatic system, such as rheumatoid arthritis, dermatitis or eczema. Cardiovascular diseases - these are diseases that affect blood flow. Some patients with cardiovascular diseases have a higher risk of developing lymphedema, such as those with DVT (deep vein thrombosis), venous leg ulcers and varicose veins (very rare). Injury and trauma - more rarely, severe skin burns or anything which results in excessive scarring may raise the risk of developing lymphedema. Diagnosing lymphedema Patients who undergo cancer treatment are commonly offered lymphedema assessment as part of their after-care treatment program. When diagnosing lymphedema the doctor may try to rule out other possible causes of swelling, including a blood clot or an infection that does not involve the lymph nodes. recently had cancer surgery or treatment involving the lymph nodes, the doctor may diagnose lymphedema based on the signs and symptoms. If there isn't an obvious cause for the lymphedema, some imaging tests may be ordered to find out what is causing the swelling, and other signs and symptoms. 
 
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